Mellad

12.11.2017 1 Comments

Once they transition their mindset toward problem driven innovation, the direction of their solution will become more commercially accessible. These alternate functions may also account for the diverse range of disease phenotypes observed when these genes are mutated. Mellad —Chief Executive Officer at Cambridge Epigenetix— was waiting in the wings to deliver his talk to an active audience of postdocs, academics and students all interested in learning more about the path to technology development and commercialisation. Cambridge Epigenetix is one of the few teams on the planet with the skills and experience to break new ground here. Often, scientific ideas are quickly outdated and surpassed with ever expanding, ever evolving knowledge. With the ability to start affordably within the founding laboratory, located at The Department of Chemistry, with access to core facilities and equipment, Cambridge Epigenetix was well placed to expand rapidly, yet organically. These two methods provided potential hits for alternative start and termination sites that were validated by PCR and DNA sequencing. It was great to see how CEGX has grown over time and to better understand the help that Cambridge Enterprise can provide to startups. One day, we will make disease optional, not inevitable.

Mellad


Mellad also stressed the importance of evolving as an organisation and continuing to innovate within the marketplace. One day, we will make disease optional, not inevitable. Founded in by Prof Shankar Balasubramanian of the Department of Chemistry, with a vision to improve healthcare through routine measurement of the epigenome, Cambridge Epigenetix is focused on developing best-in-class tools to make studying DNA methylation and DNA hydroxymethylation as easy as studying DNA sequencing. Cambridge Epigenetix is one of the few teams on the planet with the skills and experience to break new ground here. Catherine M Shanahan Nesprins Nuclear envelope spectrin-repeat proteins are a novel family of giant spectrin-repeat containing proteins. From the outset, Mellad made it clear that one must identify a problem before a solution can be leveraged into the marketplace. However emerging data suggests that the nesprins have multiple alternative start and termination sites throughout their genes allowing the generation of smaller isoforms. These studies suggest nesprins act as highly versatile tissue specific intracellular protein scaffolds and identify potential novel functions for nesprins beyond cytoplasmic-nuclear coupling. During networking, Mellad, like an epigenetic dimmer switch, began to fade into the crowds of researchers looking to talk commercialisation. Mellad expressed that once a problem is recognised, a market with unmet needs can then be identified and therefore validate the solution. Jason Mellad, CEO of spin-out Cambridge Epigenetix, discusses commercialising University research by Robert Ince On 12 September , we held the final event in our departmental roadshow series at the Department of Chemistry, discovering Cambridge Epigenetix and their pioneering research in the development of epigenetic sequencing. Once they transition their mindset toward problem driven innovation, the direction of their solution will become more commercially accessible. We show that these alternative sites are not only expressed in a tissue specific manner but by combining different sites together it is possible to create a wide array of nesprin variants. These alternate functions may also account for the diverse range of disease phenotypes observed when these genes are mutated. By cloning and expressing small novel nesprin variants into human fibroblasts and U2OS cells we show localization to actin stress-fibres, focal adhesions, microtubules, the nucleolus, nuclear matrix and the nuclear envelope NE. Often, scientific ideas are quickly outdated and surpassed with ever expanding, ever evolving knowledge. These two methods provided potential hits for alternative start and termination sites that were validated by PCR and DNA sequencing. With the ability to start affordably within the founding laboratory, located at The Department of Chemistry, with access to core facilities and equipment, Cambridge Epigenetix was well placed to expand rapidly, yet organically. Furthermore we show that the sub-cellular localization of individual nesprin variants can vary depending on the cell type, suggesting any single nesprin variant may have different functions in different cell types. Mellad —Chief Executive Officer at Cambridge Epigenetix— was waiting in the wings to deliver his talk to an active audience of postdocs, academics and students all interested in learning more about the path to technology development and commercialisation. It was great to see how CEGX has grown over time and to better understand the help that Cambridge Enterprise can provide to startups. Traditionally, researchers think of their research as a solution looking for a problem. A lean start-up is a successful start-up.

Mellad


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